Studies

The CSPRG conducts several research studies relating to bowel cancer screening and diagnosis, many of which have been running for several years. This section summarises our studies including when they ran, the types of patients involved, and the results. It also provides links to the individual study pages where you can find more detail.

Study Who was involved? Locations Dates

UKFSST Trial

375,744 men and women who were 55 to 64 years of age between November 1994 and March 1999, registered at a participating GP practice were sent an initial questionnaire or letter. Of these 170,432 men and women were randomised and either assigned to receive flexible sigmoidoscopy screening or the usual care that was offered at the time of the trial. 506 GP practices based in 14 UK centres: 11 in England, two in Wales, and one in Scotland Registered between November 1994 and March 1999. Follow-up on-going.

SIGGAR Study

9,218 men and women aged 55 years or over between March 2004 and December 2007 and were referred to one of the participating NHS hospitals with bowel cancer symptoms at the time of the SIGGAR randomised-controlled trial. 8,484 were eligible for the SIGGAR study and of these 5,448 were randomised to receive investigation of their symptoms by CT colonography or usual care. 21 NHS hospitals across England Registered between March 2004 and December 2007. Follow-up on-going as part of the SOCCER study.

SOCCER Study

Approximately 7,472 men and women who were aged 55 years or over between March 2004 and December 2007 and were referred to one of the participating NHS hospitals with bowel cancer symptoms at the time of the SIGGAR1 randomised-controlled trial. 21 NHS hospitals across England Registered between March 2004 and December 2007. Follow-up on-going.

IA and AA Studies

Retrospective data on clinical and pathology results of bowel examinations, collected on 250,000 men and women from UK hospitals and other screening studies. UK and abroad Initiated in 2006 and currently collecting some follow-up data.

FIT for Follow-Up Study

8,009 men and women aged 61 to 70 years who had a positive stool test in the NHS Bowel Cancer Screening Programme (NHS BCSP) and had a large polyp or a few small ones found at subsequent colonoscopy. These patients were told they needed a follow-up colonoscopy at 3 years and were invited to participate in the FIT for Follow-Up study. Nationwide On-going, started in February 2012.

ASCEND Study

750,000 individuals who were invited to take part in the NHS Bowel Cancer Screening Programme in England. Half received one of 4 different sets of information and the other received the usual information. Nationwide Intervention occured between November 2012 and August 2013.